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Drug Name Zenocutuzumab
Trade Name Bizengri
Synonyms MCLA-128|MCLA128|MCLA 128|zenocutuzumab-zbco
Drug Descriptions

Bizengri (zenocutuzumab) is a bispecific antibody that targets Erbb2 (Her2) and Erbb3, resulting in antibody-dependent cell-mediated cytotoxicity against tumor cells (Cancer Res 2016;76(14 Suppl):Abstract nr CT050, PMID: 32054397). Bizengri (zenocutuzumab) is FDA-approved for use in patients with advanced, unresectable, or metastatic non-small cell lung cancer harboring NRG1 fusions, and in patients with advanced, unresectable, or metastatic pancreatic adenocardinoma harboring NRG1 fusions (FDA.gov).

DrugClasses HER2 (ERBB2) Antibody 76 HER3 (ERBB3) Antibody 23
CAS Registry Number 1969309-56-5
NCIT ID C152948

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Zenocutuzumab Abiraterone Zenocutuzumab 0 1
Afatinib + Zenocutuzumab Afatinib Zenocutuzumab 0 1
Anastrozole + Zenocutuzumab Anastrozole Zenocutuzumab 0 1
Enzalutamide + Zenocutuzumab Enzalutamide Zenocutuzumab 0 1
Exemestane + Zenocutuzumab Exemestane Zenocutuzumab 0 1
Fulvestrant + Zenocutuzumab Fulvestrant Zenocutuzumab 0 1
Letrozole + Zenocutuzumab Letrozole Zenocutuzumab 0 1
Trastuzumab + Vinorelbine + Zenocutuzumab Trastuzumab Vinorelbine Zenocutuzumab 0 1
Trastuzumab + Zenocutuzumab Trastuzumab Zenocutuzumab 0 1
Zenocutuzumab Zenocutuzumab 0 1


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