Therapy Detail
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| Therapy Name | Acyclovir + AdV-tk |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Acyclovir | Zovirax | Virorax|Cargosil|BW-248U|acycloguanosine|aclovir|aciclovir | Acyclovir is a synthetic analog of guanosine, which functions as an antiviral agent by inhibiting viral DNA polymerase (NCI Drug Dictionary). | |
| AdV-tk | Aglatimagene besadenovec|GliAtak|ProstAtak|CAN-2409|CAN2409|Virafir | ADV-tk (aglatimagene besadenovec) is an engineered adenoviral vector expressing the herpes simplex virus thymidine kinase that sensitizes tumor cells to therapy with acyclic guanosine analogues (PMID: 26843484, PMID: 30883662). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02446093 | Phase II | AdV-tk + Valacyclovir Acyclovir + AdV-tk | Neoadjuvant CAN-2409 in Combination With Chemoradiation or SBRT for Borderline Resectable Pancreatic Adenocarcinoma (PaTK02) | Active, not recruiting | USA | 1 |
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