Therapy Detail
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| Therapy Name | AdV-tk + Valacyclovir |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AdV-tk | Aglatimagene besadenovec|GliAtak|ProstAtak|CAN-2409|CAN2409|Virafir | ADV-tk (aglatimagene besadenovec) is an engineered adenoviral vector expressing the herpes simplex virus thymidine kinase that sensitizes tumor cells to therapy with acyclic guanosine analogues (PMID: 26843484, PMID: 30883662). | ||
| Valacyclovir | Valtrex | Acicloftal | Valacyclovir is the prodrug of acyclovir, which is an antiviral agent that functions by inhibiting viral DNA polymerase (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03004183 | Phase II | Pembrolizumab AdV-tk + Valacyclovir | SBRT and Oncolytic Virus Therapy Before Pembrolizumab for Metastatic TNBC and NSCLC (STOMP) | Completed | USA | 0 |
| NCT03131037 | Phase I | AdV-tk + Valacyclovir | Intratumoral Gene Mediated Cytotoxic Immunotherapy in Patients With Resectable Non-Small Cell Lung Cancer | Completed | USA | 0 |
| NCT01913106 | Phase Ib/II | AdV-tk + Valacyclovir | HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer | Recruiting | USA | 0 |
| NCT02768363 | Phase II | AdV-tk + Valacyclovir Valacyclovir | Randomized Controlled Trial of ProstAtak Immunotherapy During Active Surveillance for Prostate Cancer (ULYSSES) | Active, not recruiting | USA | 1 |
| NCT01436968 | Phase III | Valacyclovir AdV-tk + Valacyclovir | Phase 3 Study of ProstAtak® Immunotherapy With Standard Radiation Therapy for Localized Prostate Cancer (PrTK03) | Active, not recruiting | USA | 1 |
| NCT02446093 | Phase II | AdV-tk + Valacyclovir Acyclovir + AdV-tk | Neoadjuvant CAN-2409 in Combination With Chemoradiation or SBRT for Borderline Resectable Pancreatic Adenocarcinoma (PaTK02) | Active, not recruiting | USA | 1 |
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