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Therapy Detail
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| Therapy Name | Cevostamab + RO7310729 + Tocilizumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cevostamab | RO7187797|BFCR4350A | CD3 Antibody 107 | Cevostamab (BFCR4350A) is a bispecific antibody that targets both FCRH5 and CD3, potentially resulting in increased anti-tumor immune response and tumor cell killing (Blood (2020) 136 (Supplement 1): 42-43). | |
| RO7310729 | XmAb24306|RO-7310729|RO 7310729 | RO7310729 (XmAb24306) is a IL15 - IL15Ralpha complex fused to a bispecific Fc domain, that stimulates proliferation of NK cells and T-cells (NCI Thesaurus). | ||
| Tocilizumab | Actemra | Atlizumab | Actemra (tocilizumab) is a humamized monoclonal antibody that targets IL-6R, resulting in decreased downstream signaling and potentially resulted in decreased tumor growth and progression (PMID: 26751841, PMID: 25658637). Actemra (tocilizumab) is FDA approved for use in treating rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, and systemic juvenile idiopathic arthritis (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05646836 | Phase I | Cevostamab + Tocilizumab Cevostamab + RO7310729 + Tocilizumab | A Study to Evaluate the Safety, Pharmacokinetics, and Activity of XmAb24306 in Combination With Cevostamab in Participants With Relapsed/Refractory Multiple Myeloma | Active, not recruiting | NOR | ISR | GRC | ESP | DNK | AUS | 1 |
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