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Therapy Name RO7616789
Synonyms
Therapy Description

RO7616789 is a trispecific antibody that targets DLL3 on tumor cells and competitively binds to CD3 and TNFRSF9 (CD137), which results in increased CD3 and TNFRSF9 (CD137) signaling and activation of T-cells, potentially leading to decreased growth of DLL3-positive tumors (PMID: 38558120).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
RO7616789 RO 7616789|RO-7616789|RG6524|RG-6524|RG 6524|ALPS-12 CD3 Antibody 99 RO7616789 is a trispecific antibody that targets DLL3 on tumor cells and competitively binds to CD3 and TNFRSF9 (CD137), which results in increased CD3 and TNFRSF9 (CD137) signaling and activation of T-cells, potentially leading to decreased growth of DLL3-positive tumors (PMID: 38558120).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05619744 Phase I RO7616789 A Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-tumor Activity of RO7616789 in Advanced Small Cell Lung Cancer and Other Neuroendocrine Carcinomas Recruiting USA | POL | ESP | DNK 1


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