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Drug Name RO7616789
Trade Name
Synonyms RO 7616789|RO-7616789|RG6524|RG-6524|RG 6524|ALPS-12
Drug Descriptions

RO7616789 is a trispecific antibody that targets DLL3 on tumor cells and competitively binds to CD3 and TNFRSF9 (CD137), which results in increased CD3 and TNFRSF9 (CD137) signaling and activation of T-cells, potentially leading to decreased growth of DLL3-positive tumors (PMID: 38558120).

DrugClasses CD3 Antibody 98
CAS Registry Number NA
NCIT ID C198701

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + RO7616789 Carboplatin RO7616789 0 0
Cisplatin + RO7616789 Cisplatin RO7616789 0 0
RO7616789 RO7616789 0 1
RO7616789 + Tocilizumab RO7616789 Tocilizumab 0 0


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