Therapy Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Therapy Name HuCART-meso cells
Synonyms
Therapy Description

HuCART-meso cells are T-lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) that targets mesothelin and contains the zeta chain of CD3 (CD3zeta) and other costimulatory domains, which potentially leads to increased antitumor immune response (PMID: 26973126, PMID: 31420241).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Drug Name Trade Name Synonyms Drug Classes Drug Description
HuCART-meso cells anti-MSLN CAR-T Cells HuCART-meso cells are T-lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) that targets mesothelin and contains the zeta chain of CD3 (CD3zeta) and other costimulatory domains, which potentially leads to increased antitumor immune response (PMID: 26973126, PMID: 31420241).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03054298 Phase I HuCART-meso cells Cyclophosphamide CAR T Cells in Mesothelin Expressing Cancers Completed USA 0
NCT05623488 Phase I HuCART-meso cells CAR T Cells in Mesothelin-Expressing Breast Cancer Recruiting USA 0
NCT03323944 Phase I HuCART-meso cells CAR T Cell Immunotherapy for Pancreatic Cancer Recruiting USA 0


Additional content available in CKB BOOST