Therapy Detail
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| Therapy Name | CARv3-TEAM-E T-cells |
| Synonyms | |
| Therapy Description |
CARv3-TEAM-E T-cells are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting EGFRvIII and a T-cell engaging antibody molecule (TEAM) comprising a bispecific T-cell engager (BiTE) targeting wild-type EGFR, which potentially induce killing of tumor cells expressing EGFRvIII and wild-type EGFR (PMID: 38477966). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CARv3-TEAM-E T-cells | CD3 Antibody 119 EGFR Antibody 73 | CARv3-TEAM-E T-cells are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting EGFRvIII and a T-cell engaging antibody molecule (TEAM) comprising a bispecific T-cell engager (BiTE) targeting wild-type EGFR, which potentially induce killing of tumor cells expressing EGFRvIII and wild-type EGFR (PMID: 38477966). |
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05660369 | Phase I | CARv3-TEAM-E T-cells | CARv3-TEAM-E T Cells in Glioblastoma | Recruiting | USA | 0 |
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