Therapy Detail
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| Therapy Name | lutetium Lu 177 vipivotide tetraxetan + ONC-392 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ONC-392 | ONC392|ONC 392 | CTLA4 Antibody 31 Immune Checkpoint Inhibitor 149 | ONC-392 is a pH-sensitive monoclonal antibody that targets CTLA4 (CD152), potentially resulting in antitumor activity (Journal for ImmunoTherapy of Cancer 2022;10). | |
| lutetium Lu 177 vipivotide tetraxetan | Pluvicto | Lu177-PSMA-617|Vipivotide tetraxetan Lu-177 | Pluvicto (lutetium Lu 177 vipivotide tetraxetan) is a radioconjugate comprising a prostate-specific membrane antigen (PSMA) inhibitor radiolabeled with Lu177, which targets PSMA expressing cells, potentially resulting in decreased tumor growth (PMID: 25883127, PMID: 26795286, PMID: 32760622). Pluvicto (lutetium Lu 177 vipivotide tetraxetan) is FDA approved for use in patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) who have received androgen receptor (AR) pathway inhibition and taxane-based chemotherapy (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05682443 | Phase II | lutetium Lu 177 vipivotide tetraxetan + ONC-392 lutetium Lu 177 vipivotide tetraxetan | ONC-392 Plus Lutetium Lu 177 Vipivotide Tetraxetan in Patients With mCRPC (PRESERVE-006) | Recruiting | USA | 0 |
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