Therapy Detail
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| Therapy Name | Carboplatin + Pemetrexed Disodium + Zipalertinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Carboplatin | Paraplatin | CBDCA | Chemotherapy - Platinum 7 | Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). |
| Pemetrexed Disodium | Alimta | LY231514|Ciambra|pemetrexed | Chemotherapy - Antimetabolite 14 | Alimta (pemetrexed disodium) is an antifolate that inhibits thymidylate synthase (NCI Drug Dictionary). |
| Zipalertinib | CLN-081|CLN 081|CLN081|TAS6417|TAS-6417 | EGFR Exon 20 Insertion Inhibitor 15 EGFR Inhibitor (Pan) 63 | Zipalertinib (CLN-081) is a small molecule tyrosine kinase inhibitor with selective activity against EGFR mutations including exon 20 insertions, potentially resulting in decreased Egfr signaling and growth inhibition of EGFR-mutant tumors (PMID: 29748209, PMID: 31467113). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05973773 | Phase III | Cisplatin + Pemetrexed Disodium Carboplatin + Pemetrexed Disodium Zipalertinib Carboplatin + Pemetrexed Disodium + Zipalertinib Pemetrexed Disodium Cisplatin + Pemetrexed Disodium + Zipalertinib | REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors) (REZILIENT3) | Recruiting | USA | TUR | ROU | POL | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CAN | BRA | BGR | BEL | 7 |
| NCT07229339 | Phase II | Carboplatin + Pemetrexed Disodium + Zipalertinib | Zipalertinib With Carboplatin and Pemetrexed for the Treatment of Resectable, Stage II-IIIB, Non-Small Cell Lung Cancer | Not yet recruiting | USA | 0 |
| NCT07128199 | Phase III | Carboplatin + Pemetrexed Disodium Cisplatin + Pemetrexed Disodium Carboplatin + Pemetrexed Disodium + Zipalertinib Cisplatin + Pemetrexed Disodium + Zipalertinib | A Study to Assess the Efficacy and Safety of Zipalertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB-IIIA NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection (REZILIENT4) | Recruiting | USA | TUR | ROU | POL | NLD | ITA | GRC | GBR | FRA | ESP | DEU | CAN | BRA | BEL | AUS | ARG | 8 |
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