Therapy Detail
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| Therapy Name | Cisplatin + Pemetrexed Disodium + Zipalertinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cisplatin | Platinol | CDDP | Chemotherapy - Platinum 7 | Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary). |
| Pemetrexed Disodium | Alimta | LY231514|Ciambra|pemetrexed | Chemotherapy - Antimetabolite 14 | Alimta (pemetrexed disodium) is an antifolate that inhibits thymidylate synthase (NCI Drug Dictionary). |
| Zipalertinib | CLN-081|CLN 081|CLN081|TAS6417|TAS-6417 | EGFR Exon 20 Insertion Inhibitor 15 EGFR Inhibitor (Pan) 63 | Zipalertinib (CLN-081) is a small molecule tyrosine kinase inhibitor with selective activity against EGFR mutations including exon 20 insertions, potentially resulting in decreased Egfr signaling and growth inhibition of EGFR-mutant tumors (PMID: 29748209, PMID: 31467113). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07128199 | Phase III | Carboplatin + Pemetrexed Disodium Cisplatin + Pemetrexed Disodium Carboplatin + Pemetrexed Disodium + Zipalertinib Cisplatin + Pemetrexed Disodium + Zipalertinib | A Study to Assess the Efficacy and Safety of Zipalertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB-IIIA NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection (REZILIENT4) | Recruiting | USA | TUR | ROU | POL | NLD | ITA | GRC | GBR | FRA | ESP | DEU | CAN | BRA | BEL | AUS | ARG | 8 |
| NCT05973773 | Phase III | Cisplatin + Pemetrexed Disodium Carboplatin + Pemetrexed Disodium Zipalertinib Carboplatin + Pemetrexed Disodium + Zipalertinib Pemetrexed Disodium Cisplatin + Pemetrexed Disodium + Zipalertinib | REZILIENT3 (REsearching ZIpaLertinib In Egfr Non-small Cell Lung Cancer Tumors) (REZILIENT3) | Recruiting | USA | TUR | ROU | POL | NLD | ITA | ISR | GRC | GBR | FRA | ESP | DEU | CAN | BRA | BGR | BEL | 7 |
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