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Drug Name | Zipalertinib |
Trade Name | |
Synonyms | CLN-081|CLN 081|CLN081|TAS6417|TAS-6417 |
Drug Descriptions |
Zipalertinib (CLN-081) is a small molecule tyrosine kinase inhibitor with selective activity against EGFR mutations including exon 20 insertions, potentially resulting in decreased Egfr signaling and growth inhibition of EGFR-mutant tumors (PMID: 29748209, PMID: 31467113). |
DrugClasses | EGFR Inhibitor (Pan) 62 |
CAS Registry Number | 1661854-97-2 |
NCIT ID | C165567 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Carboplatin + Pemetrexed Disodium + Zipalertinib | Carboplatin Pemetrexed Disodium Zipalertinib | 0 | 1 |
Cisplatin + Pemetrexed Disodium + Zipalertinib | Cisplatin Pemetrexed Disodium Zipalertinib | 0 | 1 |
Zipalertinib | Zipalertinib | 0 | 3 |