Zipalertinib
Drug Detail
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| Drug Name | Zipalertinib |
| Trade Name | |
| Synonyms | CLN-081|CLN 081|CLN081|TAS6417|TAS-6417 |
| Drug Descriptions |
Zipalertinib (CLN-081) is a small molecule tyrosine kinase inhibitor with selective activity against EGFR mutations including exon 20 insertions, potentially resulting in decreased Egfr signaling and growth inhibition of EGFR-mutant tumors (PMID: 29748209, PMID: 31467113). |
| DrugClasses | EGFR Exon 20 Insertion Inhibitor 15 EGFR Inhibitor (Pan) 63 |
| CAS Registry Number | 1661854-97-2 |
| NCIT ID | C165567 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Carboplatin + Pemetrexed Disodium + Zipalertinib | Carboplatin Pemetrexed Disodium Zipalertinib | 0 | 3 |
| Cisplatin + Pemetrexed Disodium + Zipalertinib | Cisplatin Pemetrexed Disodium Zipalertinib | 0 | 2 |
| Zipalertinib | Zipalertinib | 0 | 3 |
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