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Therapy Name Dostarlimab-gxly + EOS-448 + GSK6097608
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Dostarlimab-gxly Jemperli TSR-042 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 Jemperli (dostarlimab-gxly) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 34313545). Jemperli (dostarlimab-gxly) is FDA approved for use in patients with recurrent or advanced endometrial cancer or solid tumors harboring mismatch repair deficient (dMMR), as determined by an FDA-approved test, who have progressed on prior treatments, and in combination with Paraplatin (carboplatin) and Taxol (paclitaxel), followed by Jemperli (dostarlimab-gxly) monotherapy, in patients with primary advanced or recurrent endometrial cancer (FDA.gov).
EOS-448 EOS 448|EOS448|EOS884448|GSK4428859A|Belrestotug TIGIT Antibody 19 EOS-448 is a monoclonal antibody that binds to T cell Immunoreceptor with Ig and ITIM domains (TIGIT) and inhibits ligand interaction, potentially leading to increased antitumor immune response (Cancer Res 2020;80(16 Suppl):Abstract nr 3161; Cancer Res 2021;81(13_Suppl):Abstract nr CT118).
GSK6097608 GSK-6097608|GSK 6097608|Anti-CD96 Monoclonal Antibody GSK6097608 GSK6097608 is a monoclonal antibody targeting the tumor transmembrane protein, CD96, which may lead to inhibition of downstream signaling upon binding to CD96-expressing immune cells, thereby restoring T cell and NK cell function, and potentially resulting in an antitumor immune response (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06062420 Phase II Dostarlimab-gxly Dostarlimab-gxly + EOS-448 + GSK6097608 Dostarlimab-gxly + GSK6097608 Dostarlimab-gxly + EOS-448 A Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck- GALAXIES H&N-202 Recruiting USA | TUR | ROU | POL | NOR | ITA | HUN | GRC | FRA | FIN | ESP | DNK | DEU | CAN | BRA | ARG 4


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