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| Drug Name | Dostarlimab-gxly |
| Trade Name | Jemperli |
| Synonyms | TSR-042 |
| Drug Descriptions |
Jemperli (dostarlimab-gxly) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 34313545). Jemperli (dostarlimab-gxly) is FDA approved for use in patients with recurrent or advanced endometrial cancer or solid tumors harboring mismatch repair deficient (dMMR), as determined by an FDA-approved test, who have progressed on prior treatments, and in combination with Paraplatin (carboplatin) and Taxol (paclitaxel), followed by Jemperli (dostarlimab-gxly) monotherapy, in patients with primary advanced or recurrent endometrial cancer (FDA.gov). |
| DrugClasses | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 |
| CAS Registry Number | 2022215-59-2 |
| NCIT ID | C126799 |
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