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Drug Name | EOS-448 |
Trade Name | |
Synonyms | EOS 448|EOS448|EOS884448|GSK4428859A|Belrestotug |
Drug Descriptions |
EOS-448 is a monoclonal antibody that binds to T cell Immunoreceptor with Ig and ITIM domains (TIGIT) and inhibits ligand interaction, potentially leading to increased antitumor immune response (Cancer Res 2020;80(16 Suppl):Abstract nr 3161; Cancer Res 2021;81(13_Suppl):Abstract nr CT118). |
DrugClasses | TIGIT Antibody 19 |
CAS Registry Number | 2574438-65-4 |
NCIT ID | C176746 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Dexamethasone + EOS-448 + Iberdomide | Dexamethasone EOS-448 Iberdomide | 0 | 1 |
Dostarlimab-gxly + EOS-448 | Dostarlimab-gxly EOS-448 | 0 | 3 |
Dostarlimab-gxly + EOS-448 + GSK4381562 | Dostarlimab-gxly EOS-448 GSK4381562 | 0 | 1 |
Dostarlimab-gxly + EOS-448 + GSK6097608 | Dostarlimab-gxly EOS-448 GSK6097608 | 0 | 1 |
EOS-448 | EOS-448 | 0 | 1 |
EOS-448 + EOS100850 | EOS-448 EOS100850 | 0 | 1 |
EOS-448 + Iberdomide | EOS-448 Iberdomide | 0 | 1 |
EOS-448 + Pembrolizumab | EOS-448 Pembrolizumab | 0 | 1 |