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Therapy Name Cyclophosphamide + Fludarabine + Rimiducid + TROP2-CAR/IL15-transduced CBNK cells
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cyclophosphamide Cytoxan CPM Chemotherapy - Alkylating 18 Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary).
Fludarabine Fludara FAMP|Fludarabine phosphate Flurdara (fludarabine) is converted to 2-fluoro-ara-ATP intracellularly, which potentially inhibits DNA polymerase alpha, ribonucleotide reductase and DNA primase, leading to decreased DNA synthesis and reduced tumor growth (NCI Drug Dictionary)
Rimiducid AP1903|AP-1903|AP 1903 Rimiducid (AP1903) is a small molecule that selectively binds to mutant FKBP12 and induces dimerization and downstream signaling, which can be used to activate a safety switch in transplanted cells to potentially induce apoptosis and prevent graft-versus-host disease (PMID: 9724721, PMID: 22047558, PMID: 28697888).
TROP2-CAR/IL15-transduced CBNK cells TROP2-CAR-NK cells|TROP2-CAR-engineered IL15-transduced Cord Blood-derived NKs TROP2-CAR/IL15-transduced CBNK cells are cord blood-derived natural killer (NK) cells engineered to express IL15 and a chimeric antigen receptor (CAR) that targets TROP2, which potentially induce cytotoxicity against tumor cells expressing TROP2 (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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