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Therapy Name	SIJ777
Synonyms
Therapy Description	SIJ777 is a small molecule that inhibits BRAF class I, II, and III mutations, resulting in decreased downstream signaling, and potentially leading to increased apoptosis and decreased migration, invasion, and proliferation of tumor cells (PMID: 33917428).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
SIJ777		SIJ 777\|SIJ-777	BRAF Inhibitor 26	SIJ777 is a small molecule that inhibits BRAF class I, II, and III mutations, resulting in decreased downstream signaling, and potentially leading to increased apoptosis and decreased migration, invasion, and proliferation of tumor cells (PMID: 33917428).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF D594G	melanoma	sensitive	SIJ777	Preclinical - Cell culture	Actionable	In a preclinical study, SIJ777 inhibited Mek, Erk, and Akt phosphorylation, proliferation, migration, and invasion, and induced apoptosis in a melanoma cell line harboring BRAF D594G in culture (PMID: 33917428).	33917428
BRAF G464E	melanoma	sensitive	SIJ777	Preclinical - Cell culture	Actionable	In a preclinical study, SIJ777 inhibited Mek, Erk, and Akt phosphorylation, proliferation, migration, invasion, and colony formation, and induced apoptosis in a melanoma cell line harboring BRAF G464E in culture (PMID: 33917428).	33917428
BRAF G464V	triple-receptor negative breast cancer	sensitive	SIJ777	Preclinical - Cell culture	Actionable	In a preclinical study, SIJ777 inhibited proliferation of a triple-negative breast cancer cell line harboring BRAF G464V in culture (PMID: 33917428).	33917428
BRAF G466V	lung non-small cell carcinoma	sensitive	SIJ777	Preclinical - Cell culture	Actionable	In a preclinical study, SIJ777 inhibited proliferation of a non-small cell lung cancer cell line harboring BRAF G466V in culture (PMID: 33917428).	33917428
BRAF G469A	lung non-small cell carcinoma	sensitive	SIJ777	Preclinical - Cell culture	Actionable	In a preclinical study, SIJ777 inhibited proliferation of a non-small cell lung cancer cell line harboring BRAF G469A in culture (PMID: 33917428).	33917428
BRAF G469E	melanoma	sensitive	SIJ777	Preclinical - Cell culture	Actionable	In a preclinical study, SIJ777 inhibited Mek, Erk, and Akt phosphorylation and proliferation in a melanoma cell line harboring BRAF G469E in culture (PMID: 33917428).	33917428
BRAF V600E	melanoma	sensitive	SIJ777	Preclinical - Cell culture	Actionable	In a preclinical study, SIJ777 inhibited Mek, Erk, and Akt phosphorylation, proliferation, migration, and invasion, and induced apoptosis in melanoma cell lines harboring BRAF V600E in culture (PMID: 33917428).	33917428

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