Therapy Detail
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| Therapy Name | Belzutifan + HC-7366 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Belzutifan | Welireg | PT2977|MK-6482|PT-2977 | HIF2A Inhibitor 6 | Welireg (belzutifan) is a hypoxia inducible factor-2alpha (EPAS1, HIF2A) inhibitor that suppresses expression of HIF2A target genes, resulting in tumor regression (Mol Cancer Ther 2018,17(1 Suppl):Abstract nr B140, PMID: 31282155). Welireg (belzutifan) is FDA-approved for use in patients with von Hippel-Lindau (VHL) disease-associated renal cell carcinoma, central nervous system hemangioblastomas, or pancreatic neuroendocrine tumors that require therapy, in patients with advanced renal cell carcinoma who have received anti-PD-1 or PD-L1 therapy and VEGF inhibitor, and in adult and pediatric patients 12 years and older with pheochromocytoma or paraganglioma (FDA.gov). |
| HC-7366 | HC 7366|HC7366|HC 7366-K|HC7366-K|HC-7366-K | HC-7366 is a modulator of GCN2 kinase, which potentially inhibits tumors growth (J Clin Oncol 40, no. 16_suppl (June 01, 2022) TPS3179). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06234605 | Phase I | HC-7366 Belzutifan + HC-7366 | A Study of HC-7366 in Combination With Belzutifan (WELIRE) in Patients With Renal Cell Carcinoma | Recruiting | USA | 0 |
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