Therapy Detail
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| Therapy Name | Belzutifan + HC-7366 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Belzutifan | Welireg | PT2977|MK-6482|PT-2977 | HIF2A Inhibitor 6 | Welireg (belzutifan) is a hypoxia inducible factor-2alpha (EPAS1, HIF2A) inhibitor that suppresses expression of HIF2A target genes, resulting in tumor regression (Mol Cancer Ther 2018,17(1 Suppl):Abstract nr B140, PMID: 31282155). Welireg (belzutifan) is FDA-approved for use in patients with von Hippel-Lindau (VHL) disease-associated renal cell carcinoma, central nervous system hemangioblastomas, or pancreatic neuroendocrine tumors that require therapy, in patients with advanced renal cell carcinoma who have received anti-PD-1 or PD-L1 therapy and VEGF inhibitor, in adult and pediatric patients 12 years and older with pheochromocytoma or paraganglioma, and in combination with Keytruda (pembrolizumab) in adult patients with clear cell renal cell carcinoma (FDA.gov). |
| HC-7366 | HC 7366|HC7366|HC 7366-K|HC7366-K|HC-7366-K | HC-7366 is a modulator of GCN2 kinase, which potentially inhibits tumors growth (J Clin Oncol 40, no. 16_suppl (June 01, 2022) TPS3179). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06234605 | Phase I | HC-7366 Belzutifan + HC-7366 | A Study of HC-7366 in Combination With Belzutifan (WELIRE) in Patients With Renal Cell Carcinoma | Recruiting | USA | 0 |
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