Belzutifan
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| Drug Name | Belzutifan |
| Trade Name | Welireg |
| Synonyms | PT2977|MK-6482|PT-2977 |
| Drug Descriptions |
Welireg (belzutifan) is a hypoxia inducible factor-2alpha (EPAS1, HIF2A) inhibitor that suppresses expression of HIF2A target genes, resulting in tumor regression (Mol Cancer Ther 2018,17(1 Suppl):Abstract nr B140, PMID: 31282155). Welireg (belzutifan) is FDA-approved for use in patients with von Hippel-Lindau (VHL) disease-associated renal cell carcinoma, central nervous system hemangioblastomas, or pancreatic neuroendocrine tumors that require therapy, in patients with advanced renal cell carcinoma who have received anti-PD-1 or PD-L1 therapy and VEGF inhibitor, and in adult and pediatric patients 12 years and older with pheochromocytoma or paraganglioma (FDA.gov). |
| DrugClasses | HIF2A Inhibitor 6 |
| CAS Registry Number | 1672668-24-4 |
| NCIT ID | C135627 |
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