Belzutifan
Drug Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Drug Name | Belzutifan |
| Trade Name | Welireg |
| Synonyms | PT2977|MK-6482|PT-2977 |
| Drug Descriptions |
Welireg (belzutifan) is a hypoxia inducible factor-2alpha (EPAS1, HIF2A) inhibitor that suppresses expression of HIF2A target genes, resulting in tumor regression (Mol Cancer Ther 2018,17(1 Suppl):Abstract nr B140, PMID: 31282155). Welireg (belzutifan) is FDA-approved for use in patients with von Hippel-Lindau (VHL) disease-associated renal cell carcinoma, central nervous system hemangioblastomas, or pancreatic neuroendocrine tumors that require therapy, in patients with advanced renal cell carcinoma who have received anti-PD-1 or PD-L1 therapy and VEGF inhibitor, and in adult and pediatric patients 12 years and older with pheochromocytoma or paraganglioma (FDA.gov). |
| DrugClasses | HIF2A Inhibitor 6 |
| CAS Registry Number | 1672668-24-4 |
| NCIT ID | C135627 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Abemaciclib + Belzutifan | Abemaciclib Belzutifan | 0 | 1 |
| Belzutifan | Belzutifan | 10 | 12 |
| Belzutifan + Cabozantinib | Belzutifan Cabozantinib | 0 | 1 |
| Belzutifan + Fulvestrant | Belzutifan Fulvestrant | 0 | 1 |
| Belzutifan + HC-7366 | Belzutifan HC-7366 | 0 | 1 |
| Belzutifan + Lenvatinib | Belzutifan Lenvatinib | 0 | 2 |
| Belzutifan + Lenvatinib + Pembrolizumab | Belzutifan Lenvatinib Pembrolizumab | 0 | 3 |
| Belzutifan + Palbociclib | Belzutifan Palbociclib | 0 | 1 |
| Belzutifan + Pembrolizumab | Belzutifan Pembrolizumab | 0 | 3 |
| Belzutifan + PRT1419 | Belzutifan PRT1419 | 1 | 0 |
| Belzutifan + XL092 | Belzutifan XL092 | 0 | 1 |
CKB BOOST