Therapy Detail
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| Therapy Name | RO7617991 + Tocilizumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| RO7617991 | RO-7617991|RO 7617991 | CD3 Antibody 119 | RO7617991 is a bispecific T-cell engaging antibody that targets MAGE-A4 and CD3, which potentially leads to activation and targeting of cytotoxic T-lymphocytes to tumor cells expressing MAGE-A4, resulting in tumor cell killing (NCI Drug Dictionary). | |
| Tocilizumab | Actemra | Atlizumab | Actemra (tocilizumab) is a humamized monoclonal antibody that targets IL-6R, resulting in decreased downstream signaling and potentially resulted in decreased tumor growth and progression (PMID: 26751841, PMID: 25658637). Actemra (tocilizumab) is FDA approved for use in treating rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, and systemic juvenile idiopathic arthritis (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06372574 | Phase I | RO7617991 + Tocilizumab RO7617991 | A Study of RO7617991 in Patients With Locally Advanced or Metastatic MAGE-A4-Positive Solid Tumors | Withdrawn | 0 |
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