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Therapy Name IBI354
Synonyms
Therapy Description

IBI354 is an antibody-drug conjugate (ADC) comprising the ERBB2 (HER2) antibody trastuzumab linked to a toposiomerase I inhibitor, which potentially induces cell cycle arrest and apoptosis in Erbb2 (Her2)-expressing tumor cells and results in antitumor activity (NCI Drug Dictionary, Ann Oncol (2024) 35 (suppl_2): S467-468).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
IBI354 IBI-354|IBI 354 HER2 (ERBB2) Antibody-Drug Conjugate 31 IBI354 is an antibody-drug conjugate (ADC) comprising the ERBB2 (HER2) antibody trastuzumab linked to a toposiomerase I inhibitor, which potentially induces cell cycle arrest and apoptosis in Erbb2 (Her2)-expressing tumor cells and results in antitumor activity (NCI Drug Dictionary, Ann Oncol (2024) 35 (suppl_2): S467-468).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05636215 Phase Ib/II IBI354 A First-in-human Study of IBI354 in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors Recruiting AUS 1


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