Therapy Detail
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| Therapy Name | Gilteritinib + MI-3454 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Gilteritinib | Xospata | ASP2215 | AXL Inhibitor 30 FLT3 Inhibitor 69 | Xospata (gilteritinib) is a small molecule inhibitor of FLT3 and AXL that has activity against FLT3-ITD, FLT3 F691L, and FLT3 D835 mutations, potentially resulting in decreased tumor growth (J Clin Oncol 32:5s, 2014 (suppl; abstr 7070), PMID: 25891481). Xospata (gilteritinib) is FDA approved for use in patients with relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation (ITD, D835X, and I836X) (FDA.gov). |
| MI-3454 | MI 3454|MI3454 | MEN1-KMT2A Inhibitor 8 | MI-3454 binds to Menin (MEN1) and inhibits its interaction with KMT2A (MLL), potentially leading to decreased growth of tumor cells harboring KMT2A (MLL) or NUP98 rearrangements or NPM1 mutations, and inhibition of tumor growth (PMID: 31855575, PMID: 38890447). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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