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Drug Name | MI-3454 |
Trade Name | |
Synonyms | MI 3454|MI3454 |
Drug Descriptions |
MI-3454 binds to Menin (MEN1) and inhibits its interaction with KMT2A (MLL), potentially leading to decreased growth of tumor cells harboring KMT2A (MLL) or NUP98 rearrangements or NPM1 mutations, and inhibition of tumor growth (PMID: 31855575, PMID: 38890447). |
DrugClasses | MEN1-KMT2A Inhibitor 8 |
CAS Registry Number | 2134169-43-8 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Gilteritinib + MI-3454 | Gilteritinib MI-3454 | 0 | 0 |
MI-3454 | MI-3454 | 0 | 0 |
MI-3454 + Palbociclib | MI-3454 Palbociclib | 0 | 0 |