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| Drug Name | XAV939 |
| Trade Name | |
| Synonyms | XAV-939 |
| Drug Descriptions |
XAV939 selectively inhibits Wnt/beta-catenin-mediated signaling by inhibiting tankyrase1/2, thus stabilizing axin and stimulating beta-catenin degradation (PMID: 19759537, PMID: 32681294). |
| DrugClasses | Tankyrase Inhibitor 11 |
| CAS Registry Number | 284028-89-3 |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Everolimus + XAV939 | Everolimus XAV939 | 0 | 0 |
| Imatinib + XAV939 | Imatinib XAV939 | 1 | 0 |
| Palbociclib + XAV939 | Palbociclib XAV939 | 0 | 0 |
| unspecified PD-1 antibody + XAV939 | XAV939 unspecified PD-1 antibody | 0 | 0 |
| Vandetanib + XAV939 | Vandetanib XAV939 | 0 | 0 |
| XAV939 | XAV939 | 8 | 0 |
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