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Therapy Name Ceritinib + hALK.CAR T cells
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Ceritinib Zykadia LDK378 ALK Inhibitor 33 ROS1 Inhibitor 22 Zykadia (ceritinib) inhibits ALK, including ALK mutations and fusions, and has additional activity against ROS1 fusions, potentially resulting in decreased tumor cell growth (PMID: 25322323, PMID: 26372962). Zykadia (ceritinib) is FDA approved for ALK-positive (rearrangements and fusions) metastatic non-small cell lung cancer (FDA.gov).
hALK.CAR T cells hALK.CAR T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting ALK linked to the CD8 alpha hinge and transmembrane domain, CD28 costimulatory domain, and CD3zeta signaling domain, which potentially induces cytoxicity against tumor cells with high Alk expression (PMID: 38039964).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK R1275Q neuroblastoma sensitive Ceritinib + hALK.CAR T cells Preclinical - Cell culture Actionable In a preclinical study, Zykadia (ceritinib) treatment resulted in increased death of neuroblastoma cells harboring ALK R1275Q when co-cultured with hALK.CAR T cells compared to control CAR-T cells in culture (PMID: 38039964). 38039964
ALK F1174L neuroblastoma sensitive Ceritinib + hALK.CAR T cells Preclinical - Cell culture Actionable In a preclinical study, Zykadia (ceritinib) treatment resulted in increased death of neuroblastoma cells harboring ALK F1174L when co-cultured with hALK.CAR T cells compared to control CAR-T cells in culture (PMID: 38039964). 38039964

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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