Therapy Detail
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| Therapy Name | LV20.19 CAR-T cells + Pirtobrutinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| LV20.19 CAR-T cells | Autologous CAR-20/19-T cells|4-1BB-CD3zeta LV20.19 CAR T cells | CD19 Immune Cell Therapy 65 CD20 Immune Cell Therapy 13 | LV20.19 CAR-T cells are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) comprising single chain variable fragments targeting CD19 and CD20 coupled to CD3zeta and TNFRSF9 (CD137; 4-1BB) signaling domains, which potentially induce antitumor activity (PMID: 33020647, NCI Drug Dictionary). | |
| Pirtobrutinib | Jaypirca | LOXO-305|LOXO 305|LOXO305|RXC005|REDX08608 | BTK inhibitor 38 | Jaypirca (pirtobrutinib) selectively inhibits the activation of BTK, which may result in decreased tumor growth (PMID: 32170458, PMID: 33676628). Jaypirca (pirtobrutinib) is FDA approved for use in patients with relapsed or refractory mantle cell lymphoma who had received at least two lines of systemic therapy, and in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) who have received at least two prior lines of therapy (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05990465 | Phase I | LV20.19 CAR-T cells + Pirtobrutinib | LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell Malignancies | Recruiting | USA | 0 |
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