Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name Pirtobrutinib
Trade Name Jaypirca
Synonyms LOXO-305|LOXO 305|LOXO305|RXC005|REDX08608
Drug Descriptions

Jaypirca (pirtobrutinib) selectively inhibits the activation of BTK, which may result in decreased tumor growth (PMID: 32170458, PMID: 33676628). Jaypirca (pirtobrutinib) is FDA approved for use in patients with relapsed or refractory mantle cell lymphoma who had received at least two lines of systemic therapy, and in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) who have received at least two prior lines of therapy (FDA.gov).

DrugClasses BTK inhibitor 37
CAS Registry Number 2101700-15-4
NCIT ID C158617

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Brexucabtagene autoleucel + Pirtobrutinib Brexucabtagene autoleucel Pirtobrutinib 0 1
Cyclophosphamide + Doxorubicin + Pirtobrutinib + Prednisone + Rituximab + Vincristine Sulfate Cyclophosphamide Doxorubicin Pirtobrutinib Prednisone Rituximab Vincristine Sulfate 0 1
Glofitamab-gxbm + Obinutuzumab + Pirtobrutinib Glofitamab-gxbm Obinutuzumab Pirtobrutinib 0 1
Glofitamab-gxbm + Pirtobrutinib Glofitamab-gxbm Pirtobrutinib 0 1
LOXO-338 + Pirtobrutinib LOXO-338 Pirtobrutinib 0 1
Obinutuzumab + Pirtobrutinib Obinutuzumab Pirtobrutinib 0 1
Obinutuzumab + Pirtobrutinib + Venetoclax Obinutuzumab Pirtobrutinib Venetoclax 0 1
Pirtobrutinib Pirtobrutinib 2 8
Pirtobrutinib + Rituximab Pirtobrutinib Rituximab 0 2
Pirtobrutinib + Rituximab + Venetoclax Pirtobrutinib Rituximab Venetoclax 0 3
Pirtobrutinib + Venetoclax Pirtobrutinib Venetoclax 0 6


Additional content available in CKB BOOST