Therapy Detail
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| Therapy Name | 225Ac-SSO110 + Atezolizumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| 225Ac-SSO110 | 225AcSSO110|[225Ac]Ac-SSO110 | 225Ac-SSO110 is a radioconjugate comprising the alpha-radiation emitting radionuclide actinium-225 linked to the somatostatin receptor 2 (SSTR2) antagonist SSO110 (DOTA-JR11), which delivers radiation to SSTR2-expressing tumor cells, potentially resulting in decreased tumor growth (Journal of Nuclear Medicine June 2024, 65 (supplement 2) 242038). | ||
| Atezolizumab | Tecentriq | RG7446|MPDL3280A | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 | Tecentriq (atezolizumab) is a monoclonal antibody against PD-L1 (CD274), preventing activation of its receptor, potentially enhancing T-cell-mediated immune response to neoplasms and inhibiting T-cell inactivation (PMID: 29449897). Tecentriq (atezolizumab) is FDA approved for use in PD-L1 positive (IC >/= 5%) advanced or metastatic cisplatin ineligible urothelial carcinoma, in advanced or metastatic urothelial carcinoma not eligible for chemotherapy, in metastatic non-small cell lung cancer (NSCLC) progressed on platinum-containing therapy, as first-line therapy in metastatic PD-L1-high (TC>/=50% or IC>/=10%) NSCL without EGFR or ALK alterations, for adjuvant treatment in patients with PD-L1-positive (>=1% tumor cell expression) NSCLC, in combination with bevacizumab, paclitaxel, and carboplatin as first-line therapy for non-squamous NSCLC with no EGFR or ALK aberrations, in combination with paclitaxel protein-bound and carboplatin in metastatic non-squamous NSCLC with no EGFR or ALK aberrations, in combination with carboplatin and etoposide in extensive-stage small cell lung cancer (ES-SCLC), in combination with bevacizumab in hepatocellular carcinoma without prior systemic therapy, in combination with Cotellic (cobimetinib) and Zelboraf (vemurafenib) in unresectable or metastatic BRAF V600-mutated melanoma, in combination with lurbinectedin for ES-SCLC, and in pediatric and adult patients with unresectable or metastatic alveolar soft part sarcoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06939036 | Phase Ib/II | 225Ac-SSO110 + Retifanlimab 225Ac-SSO110 + Durvalumab 225Ac-SSO110 + Atezolizumab 225Ac-SSO110 + Pembrolizumab 225Ac-SSO110 + Avelumab | Study of 225Ac-SS0110 in Subjects With ES-SCLC or MCC (SANTANA-225 ) (SANTANA-225) | Recruiting | USA | AUS | 0 |
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