Therapy Detail
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| Therapy Name | 225Ac-SSO110 + Durvalumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| 225Ac-SSO110 | 225AcSSO110|[225Ac]Ac-SSO110 | 225Ac-SSO110 is a radioconjugate comprising the alpha-radiation emitting radionuclide actinium-225 linked to the somatostatin receptor 2 (SSTR2) antagonist SSO110 (DOTA-JR11), which delivers radiation to SSTR2-expressing tumor cells, potentially resulting in decreased tumor growth (Journal of Nuclear Medicine June 2024, 65 (supplement 2) 242038). | ||
| Durvalumab | Imfinzi | MEDI4736 | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 | Imfinzi (durvalumab) is a monoclonal antibody that binds to and inhibits PD-L1 (CD274), potentially resulting in increased immune response to tumors (PMID: 25943534, PMID: 28214651). Imfinzi (durvalumab) is FDA-approved for use in patients with unresectable, stage III non-small cell lung cancer, and limited-stage small cell lung cancer, in combination with Imjudo (tremelimumab) and platinum-based chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC) without sensitizing EGFR or ALK mutations, in combination with platinum-based chemotherapy as neoadjuvant therapy followed by surgery and adjuvant Imfinzi (durvalumab) in patients with resectable non-small cell lung cancer, in combination with etoposide and carboplatin or cisplatin in patients with extensive stage small cell lung cancer, in combination with cisplatin and gemcitabine in patients with locally advanced or metastatic biliary tract cancer, in combination with Imjudo (tremelimumab) in adult patients with unresectable hepatocellular carcinoma, in combination with carboplatin plus paclitaxel followed by single-agent Imfinzi (durvalumab) in adult patients with mismatch repair deficient endometrial cancer, in combination with cisplatin plus gemcitabine followed by single-agent Imfinzi (durvalumab) in adult patients with muscle invasive bladder cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06939036 | Phase Ib/II | 225Ac-SSO110 + Retifanlimab 225Ac-SSO110 + Durvalumab 225Ac-SSO110 + Atezolizumab 225Ac-SSO110 + Pembrolizumab 225Ac-SSO110 + Avelumab | Study of 225Ac-SS0110 in Subjects With ES-SCLC or MCC (SANTANA-225 ) (SANTANA-225) | Recruiting | USA | AUS | 0 |
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