Therapy Detail
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| Therapy Name | 225Ac-SSO110 + Avelumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| 225Ac-SSO110 | 225AcSSO110|[225Ac]Ac-SSO110 | 225Ac-SSO110 is a radioconjugate comprising the alpha-radiation emitting radionuclide actinium-225 linked to the somatostatin receptor 2 (SSTR2) antagonist SSO110 (DOTA-JR11), which delivers radiation to SSTR2-expressing tumor cells, potentially resulting in decreased tumor growth (Journal of Nuclear Medicine June 2024, 65 (supplement 2) 242038). | ||
| Avelumab | Bavencio | MSB0010718C | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 | Bavencio (avelumab) is a monoclonal antibody binds to human immunosuppressive ligand programmed death-ligand 1 (PD-L1, CD274) and blocks protein signaling, resulting in immune regulation and antitumor immunity (PMID: 26014098). Bavencio (avelumab) is FDA-approved for use in adult and pediatric patients of 12 years or older with metastatic Merkel cell carcinoma, as maintenance therapy in locally advanced or metastatic urothelial carcinoma (UC), in locally advanced or metastatic UC that progressed following chemotherapy, and in combination with axitinib as first-line therapy in advanced renal cell carcinoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06939036 | Phase Ib/II | 225Ac-SSO110 + Retifanlimab 225Ac-SSO110 + Durvalumab 225Ac-SSO110 + Atezolizumab 225Ac-SSO110 + Pembrolizumab 225Ac-SSO110 + Avelumab | Study of 225Ac-SS0110 in Subjects With ES-SCLC or MCC (SANTANA-225 ) (SANTANA-225) | Recruiting | USA | AUS | 0 |
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