Therapy Detail
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| Therapy Name | MK-2010 |
| Synonyms | |
| Therapy Description |
MK-2010 (LM-299) is a bispecific antibody targeting PDCD1 (PD-1) and VEGF, which potentially inhibits tumor growth (Cancer Res (2026) 86 (8_Supplement): CT057; NCT06650566). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| MK-2010 | LM-299|LM 299|LM299|MK2010|MK 2010 | PD-L1/PD-1 antibody 140 VEGF Antibody 18 | MK-2010 (LM-299) is a bispecific antibody targeting PDCD1 (PD-1) and VEGF, which potentially inhibits tumor growth (Cancer Res (2026) 86 (8_Supplement): CT057; NCT06650566). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06650566 | Phase Ib/II | MK-2010 | Study of LM-299 in Subjects Advanced Malignant Tumors | Recruiting | AUS | 1 |
| NCT07793942 | Phase II | Belzutifan + MK-2010 MK-2010 Carboplatin + MK-2010 + Paclitaxel Cisplatin + Gemcitabine + MK-2010 Cisplatin + MK-2010 + Pemetrexed Disodium Carboplatin + MK-2010 + Nab-paclitaxel Fluorouracil + Leucovorin + MK-2010 + Oxaliplatin Carboplatin + MK-2010 + Pemetrexed Disodium Fluorouracil + Levoleucovorin + MK-2010 + Oxaliplatin Fluorouracil + Levoleucovorin + Oxaliplatin + Pembrolizumab Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab | A Clinical Trial of MK-2010 Alone and With Other Treatments in Participants With Advanced Solid Tumors (MK-2010-002) | Recruiting | USA | CHE | CAN | 0 |
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