Therapy Detail
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| Therapy Name | Carboplatin + LM-299 + Paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Carboplatin | Paraplatin | CBDCA | Chemotherapy - Platinum 7 | Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). |
| LM-299 | LM 299|LM299|MK2010|MK-2010|MK 2010 | PD-L1/PD-1 antibody 138 VEGF Antibody 17 | LM-299 is a bispecific antibody targeting PDCD1 (PD-1) and VEGF, which potentially inhibits tumor growth (Cancer Res (2026) 86 (8_Supplement): CT057; NCT06650566). | |
| Paclitaxel | Taxol | 7-Epipaclitaxel | Antimicrotubule Agent 14 BCL2 Family Inhibitor 6 | Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07793942 | Phase II | Belzutifan + LM-299 LM-299 Carboplatin + LM-299 + Paclitaxel Cisplatin + Gemcitabine + LM-299 Cisplatin + LM-299 + Pemetrexed Disodium Carboplatin + LM-299 + Nab-paclitaxel Fluorouracil + Leucovorin + LM-299 + Oxaliplatin Carboplatin + LM-299 + Pemetrexed Disodium Fluorouracil + Levoleucovorin + LM-299 + Oxaliplatin Fluorouracil + Levoleucovorin + Oxaliplatin + Pembrolizumab Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab | A Clinical Trial of MK-2010 Alone and With Other Treatments in Participants With Advanced Solid Tumors (MK-2010-002) | Not yet recruiting | USA | CHE | 0 |
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