Therapy Detail
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| Therapy Name | Linvoseltamab + Pomalidomide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Linvoseltamab | Lynozyfic | REGN5458|REGN-5458|REGN 5458|Anti-BCMA/CD3 BiTE|linvoseltamab-gcpt | CD3 Antibody 119 TNFRSF17 Antibody 22 | Lynozyfic (linvoseltamab) is a bispecific antibody that binds to TNFRSF17 (BCMA) and CD3 with potential antitumor activity (Blood (2019) 134 (Supplement_1): 3176). Lynozyfic (linvoseltamab) is FDA-approved for use in patients with previously-treated relapsed or refractory multiple myeloma (FDA.gov). |
| Pomalidomide | Pomalyst | CC-4047 | Pomalyst (pomalidomide) is a thalidomide derivative that inhibits angiogenesis and modulates immune response, potentially lead to antitumor activity (PMID: 30069630). Pomalyst (pomalidomide) is FDA approved for use in patients with Kaposi's sarcoma who failed HAART or are HIV-negative, and in combination with dexamethasone in patients with multiple myeloma who had 2 or more prior therapies (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05137054 | Phase I | Cevostamab + Linvoseltamab Cemiplimab + Linvoseltamab Linvoseltamab + Nirogacestat Isatuximab + Linvoseltamab Fianlimab + Linvoseltamab Lenalidomide + Linvoseltamab Bortezomib + Linvoseltamab Linvoseltamab + Pomalidomide Daratumumab + Linvoseltamab Carfilzomib + Linvoseltamab | REGN5458 (Anti-BCMA x Anti-CD3 Bispecific Antibody) Plus Other Cancer Treatments for Participants With Relapsed/Refractory Multiple Myeloma | Recruiting | USA | ISR | GRC | FRA | ESP | 0 |
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