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Therapy Name Cemiplimab + Fianlimab + Sarilumab + Ubamatamab
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cemiplimab Libtayo REGN2810|SAR439684 Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 Libtayo (cemiplimab) is a human antibody that targets PD-1 (PDCD1) and prevents interaction with PD-L1 (CD274) and PD-L2 (PDCD1LG2), potentially resulting in increased anti-tumor immune response and decreased tumor growth (PMID: 28265006). Libtayo (cemiplimab) is FDA approved for use in patients with cutaneous squamous cell carcinoma, who are not not eligible for curative surgery or radiation, in patients with locally advanced or metastatic basal cell carcinoma who have received or are not eligible for a hedgehog pathway inhibitor, as first-line treatment in patients with advanced non-small cell lung cancer (NSCLC) with high PD-L1 expression (TPS>=50%) and no EGFR, ALK, or ROS1 aberrations, and in combination with platinum-based chemotherapy as first-line treatment for patients with NSCLC without EGFR, ALK, or ROS1 alterations (FDA.gov).
Fianlimab REGN 3767|R3767|REGN3767 Immune Checkpoint Inhibitor 150 LAG3 Antibody 19 Fianlimab (REGN3767 ) is a monoclonal antibody that targets LAG3, potentially resulting in increased anti-tumor immune response (PMID: 31395688).
Sarilumab Kevzara REGN88|SAR153191 Kevzara (sarilumab) is a monoclonal antibody that targets interleukin-6 receptor (IL6R), resulting in decreased downstream signaling and potentially leading to inhibition of tumor growth (Cancer Res 2012;72(8 Suppl):Abstract nr 2723). Kevzara (sarilumab) is FDA approved for use in patients with active rheumatoid arthritis (FDA.gov).
Ubamatamab REGN-4018|REGN 4018|REGN4018 CD3 Antibody 119 MUC16 Targeted Therapy 10 Ubamatamab (REGN4018) is a bispecific antibody that binds MUC16 (CA125) on tumor cells and CD3 on T-cells to stimulate T-cell killing of MUC16-expressing tumor cells (AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1777, PMID: 31217340).

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06787612 Phase II Bevacizumab + Sarilumab + Ubamatamab Sarilumab + Ubamatamab Pegylated liposomal doxorubicin + Sarilumab + Ubamatamab Cemiplimab + Fianlimab + Sarilumab + Ubamatamab Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer Recruiting USA | TUR 2


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