Therapy Detail
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| Therapy Name | ARV-766 + lutetium Lu 177 vipivotide tetraxetan |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ARV-766 | ARV 766|ARV766|Luxdegalutamide|JSB462 | Hormone - Anti-androgens 57 | ARV-766 is a proteolysis-targeted chimera (PROTAC) that induces degradation of wild-type androgen receptor (AR) and AR ligand-binding domain mutants, which potentially results in antitumor activity (J Clin Oncol 2024 42:16_suppl, 5011). | |
| lutetium Lu 177 vipivotide tetraxetan | Pluvicto | Lu177-PSMA-617|Vipivotide tetraxetan Lu-177 | Pluvicto (lutetium Lu 177 vipivotide tetraxetan) is a radioconjugate comprising a prostate-specific membrane antigen (PSMA) inhibitor radiolabeled with Lu177, which targets PSMA expressing cells, potentially resulting in decreased tumor growth (PMID: 25883127, PMID: 26795286, PMID: 32760622). Pluvicto (lutetium Lu 177 vipivotide tetraxetan) is FDA approved for use in patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) who have received androgen receptor (AR) pathway inhibition (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07047118 | Phase II | ARV-766 + lutetium Lu 177 vipivotide tetraxetan lutetium Lu 177 vipivotide tetraxetan | A Study of JSB462 (Luxdegalutamide) Plus Lutetium (177Lu) Vipivotide Tetraxetan in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC) | Recruiting | USA | NLD | ITA | ISR | FRA | ESP | DEU | CZE | CAN | AUT | AUS | 3 |
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