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| Therapy Name | Etentamig + Iberdomide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Etentamig | TNB-383B|TNB383B|TNB 383B|ABBV383|ABBV 383|ABBV-383 | CD3 Antibody 119 TNFRSF17 Antibody 22 | Etentamig (ABBV-383) is a bispecific antibody that targets alpha CD3 and BCMA, potentially resulting in the activation of T-cells and tumor cell lysis (Journal of Clinical Oncology 2018 36:15_suppl, 8034-8034, PMID: 36029527). | |
| Iberdomide | CC220|CC-220|CC 220 | Iberdomide (CC-220) binds to the ubiquitin E3 ligase complex member Cereblon (CRBN), which may lead to increased ubiquitination and degradation of transcription factors, resulting in decreased B-cell proliferation (PMID: 29945920, PMID: 28848067, PMID: 31719682). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06896916 | Phase I | Etentamig + Iberdomide | Study of Intravenously (IV) Infused Etentamig in Combination With an Oral Cereblon E3 Ligase Modulatory Drug (CELMoD) Agent Assessing Adverse Events and Change in Disease Activity in Adult Participants With Relapsed or Refractory Multiple Myeloma | Recruiting | USA | NOR | NLD | FRA | CAN | AUS | 1 |
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