Therapy Detail
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| Therapy Name | Everolimus + Ripretinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Everolimus | Afinitor | RAD001|Zortress | mTORC1 Inhibitor 9 | Afinitor (everolimus) binds to FKBP-12 and allosterically inhibits mTOR, leading to decreased mTORC1 signaling and potentially resulting in decreased tumor cell growth (PMID: 17766661, PMID: 28400999). Afinitor (everolimus) is FDA approved for use in neuroendocrine tumors of pancreatic, lung or gastrointestinal tract origin, advanced renal cell carcinoma, in adult and pediatric patients aged 1 year and older with tuberous sclerosis complex who have subependymal giant cell astrocytoma, and in combination with Aromasin (exemestane) in hormone receptor-positive, HER2-negative breast cancer (FDA.gov). |
| Ripretinib | Qinlock | DCC-2618|DCC2618 | KIT Inhibitor 57 PDGFR-alpha Inhibitor 10 | Qinlock (ripretinib) is a dual inhibitor of KIT and PDGFRa, resulting in growth inhibition and anti-tumor effects (PMID: 29439183, PMID: 31085175, PMID: 31201392). Qinlock (ripretinib) is FDA approved for use in patients with advanced gastrointestinal stromal tumor who received 3 or more prior kinase inhibitor therapies (FDA.gov) |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT Y553_K558del TSC1 G464fs | gastrointestinal stromal tumor | predicted - sensitive | Everolimus + Ripretinib | Case Reports/Case Series | Actionable | In a clinical case study, treatment with the combination of Qinlock (ripretinib) and Afinitor (everolimus) resulted in stable disease with a progression-free survival of 8.5 months in a patient with recurrent gastrointestinal stromal tumor harboring KIT Y553_K558del and TSC1 G464fs (PMID: 40700673; NCT0253467). | 40700673 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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