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Drug Detail
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| Drug Name | Ripretinib |
| Trade Name | Qinlock |
| Synonyms | DCC-2618|DCC2618 |
| Drug Descriptions |
Qinlock (ripretinib) is a dual inhibitor of KIT and PDGFRa, resulting in growth inhibition and anti-tumor effects (PMID: 29439183, PMID: 31085175, PMID: 31201392). Qinlock (ripretinib) is FDA approved for use in patients with advanced gastrointestinal stromal tumor who received 3 or more prior kinase inhibitor therapies (FDA.gov) |
| DrugClasses | KIT Inhibitor 57 PDGFR-alpha Inhibitor 10 |
| CAS Registry Number | 1442472-39-0 |
| NCIT ID | C124067 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Binimetinib + Ripretinib | Binimetinib Ripretinib | 0 | 1 |
| DCC-3116 + Ripretinib | DCC-3116 Ripretinib | 0 | 1 |
| Repaglinide + Ripretinib | Repaglinide Ripretinib | 0 | 1 |
| Ripretinib | Ripretinib | 79 | 4 |
| Ripretinib + Selumetinib | Ripretinib Selumetinib | 0 | 0 |
| Ripretinib + Sunitinib | Ripretinib Sunitinib | 5 | 0 |
| Ripretinib + Trametinib | Ripretinib Trametinib | 0 | 0 |
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