Therapy Detail
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| Therapy Name | Bevacizumab + GSK5733584 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bevacizumab | Avastin | VEGF Antibody 15 VEGFR Inhibitor (Pan) 36 | Avastin (bevacizumab) is a monoclonal antibody that binds VEGF and inhibits binding to VEGFR, potentially resulting in decreased tumor growth (PMID: 15136787). Avastin (bevacizumab) is FDA approved for use in colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, cervical carcinoma, and ovarian cancer, and in combination with carboplatin and paclitaxel in epithelial ovarian, fallopian tube, or primary peritoneal cancer (FDA.gov). | |
| GSK5733584 | GSK 5733584|GSK-5733584|HS-20089 | GSK5733584 is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting VTCN1 (B7-H4) linked to a topoisomerase I inhibitor, which potentially induces apoptosis in VTCN1 (B7-H4)-expressing tumor cells (Cancer Res (2025) 85 (8_Supplement_2): CT188, NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06796907 | Phase Ib/II | GSK5733584 Bevacizumab + GSK5733584 Dostarlimab-gxly + GSK5733584 | A Study of GSK5733584 in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2) | Recruiting | TUR | SWE | POL | NOR | NLD | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CAN | BRA | BEL | AUS | ARG | 3 |
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