Therapy Detail
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| Therapy Name | GSK5733584 |
| Synonyms | |
| Therapy Description |
GSK5733584 is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting VTCN1 (B7-H4) linked to a topoisomerase I inhibitor, which potentially induces apoptosis in VTCN1 (B7-H4)-expressing tumor cells (Cancer Res (2025) 85 (8_Supplement_2): CT188, NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| GSK5733584 | GSK 5733584|GSK-5733584|HS-20089 | GSK5733584 is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting VTCN1 (B7-H4) linked to a topoisomerase I inhibitor, which potentially induces apoptosis in VTCN1 (B7-H4)-expressing tumor cells (Cancer Res (2025) 85 (8_Supplement_2): CT188, NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06796907 | Phase Ib/II | GSK5733584 Bevacizumab + GSK5733584 Dostarlimab-gxly + GSK5733584 | A Study of GSK5733584 in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2) | Recruiting | TUR | SWE | POL | NOR | NLD | GRC | GBR | FRA | FIN | ESP | DNK | DEU | CAN | BRA | BEL | AUS | ARG | 3 |
| NCT01042379 | Phase II | GSK5733584 Zanidatamab Cemiplimab + VSV-hIFNbeta-NIS Cyclophosphamide + Doxorubicin + Paclitaxel + Trastuzumab ARX-788 Letrozole + Vepdegestrant Lasofoxifene Datopotamab deruxtecan + Durvalumab Abemaciclib + Vepdegestrant Dostarlimab-gxly + GSK5733584 Cemiplimab + Paclitaxel + Sarilumab Abemaciclib + Z-endoxifen HCl DAN-222 + Niraparib Datopotamab deruxtecan Vepdegestrant AZD2936 + Trastuzumab deruxtecan Z-endoxifen HCl | I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (I-SPY) | Recruiting | USA | 0 |
| NCT06431594 | Phase I | GSK5733584 | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Participants With Advanced Solid Tumors | Recruiting | USA | SWE | NLD | ITA | GBR | FRA | FIN | ESP | CAN | BEL | AUS | ARG | 2 |
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