Therapy Detail
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| Therapy Name | AMG 509 + Enzalutamide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AMG 509 | AMG509|AMG-509|Xaluritamig | CD3 Antibody 119 | AMG 509 is a bispecific T-cell engager targeting STEAP1 and CD3, potentially resulting in increased immune response against STEAP1-expressing tumors cells (PMID: 37861452). | |
| Enzalutamide | Xtandi | MDV3100|ASP9785 | Hormone - Anti-androgens 57 | Xtandi (enzalutamide) is a second-generation small molecule inhibitor of androgen receptor, thereby resulting in decreased tumor growth (PMID: 24009414, PMID: 25945058). Xtandi (enzalutamide) is FDA-approved for use in patients with castration-resistant prostate cancer, metastatic hormone-sensitive prostate cancer, and non-metastatic castration-sensitive prostate cancer with biochemical recurrence at high risk for metastasis (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04221542 | Phase I | AMG 509 Abiraterone + AMG 509 AMG 509 + Enzalutamide | Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer | Recruiting | USA | ESP | DEU | CHE | AUS | 5 |
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