Therapy Detail
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| Therapy Name | Empagliflozin + Fulvestrant + Inavolisib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Empagliflozin | BI-10773|BI10773|BI 10773 | Empagliflozin is an SLC5A2 (SGLT2) inhibitor, which potentially inhibits proliferation and migration and induces apoptosis of tumor cells and reduces tumor growth (PMID: 32931885). | ||
| Fulvestrant | Faslodex | ICI 182,780 | Hormone - Anti-estrogens 31 | Faslodex (fulvestrant) is a competitive inhibitor of estrogen that binds and deforms estrogen receptors, and causes inhibition of growth in cultured estrogen-sensitive breast cancer cells and is FDA approved for use in patients with hormone receptor-positive breast cancer (FDA.gov). |
| Inavolisib | Itovebi | GDC-0077|RO7113755|RG6114|GDC0077|GDC 0077 | PIK3CA inhibitor 27 | Itovebi (inavolisib) inhibits PIK3CA, with selectivity for mutant PIK3CA over wild-type PIK3CA, potentially resulting in increased apoptosis and decreased growth of PIK3CA-mutant tumors (PMID: 36455032). Itovebi (inavolisib) in combination with Ibrance (palbociclib) and Faslodex (fulvestrant) is FDA-approved for use in patients with endocrine-resistant, hormone receptor (HR)-positive, ERBB2 (HER2)-negative, locally advanced or metastatic breast cancer harboring PIK3CA mutations (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03424005 | Phase Ib/II | Fulvestrant + Inavolisib + PF-07220060 Fulvestrant + Inavolisib + Metformin Fulvestrant + Inavolisib + Metformin + Palbociclib Empagliflozin + Fulvestrant + Inavolisib Empagliflozin + Fulvestrant + Inavolisib + Palbociclib Inavolisib + Trastuzumab deruxtecan Abemaciclib + Inavolisib + Letrozole Fulvestrant + Inavolisib + Ribociclib Abemaciclib + Fulvestrant + Inavolisib Inavolisib + Letrozole + Ribociclib | A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer (Morpheus-panBC) | Recruiting | USA | ISR | GBR | FRA | ESP | DEU | AUS | 2 |
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