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| Drug Name | Inavolisib |
| Trade Name | Itovebi |
| Synonyms | GDC-0077|RO7113755|RG6114|GDC0077|GDC 0077 |
| Drug Descriptions |
Itovebi (inavolisib) inhibits PIK3CA, with selectivity for mutant PIK3CA over wild-type PIK3CA, potentially resulting in increased apoptosis and decreased growth of PIK3CA-mutant tumors (PMID: 36455032). Itovebi (inavolisib) in combination with Ibrance (palbociclib) and Faslodex (fulvestrant) is FDA-approved for use in patients with endocrine-resistant, hormone receptor (HR)-positive, ERBB2 (HER2)-negative, locally advanced or metastatic breast cancer harboring PIK3CA mutations (FDA.gov). |
| DrugClasses | PIK3CA inhibitor 24 |
| CAS Registry Number | 2060571-02-8 |
| NCIT ID | C132166 |
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