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Therapy Name Fulvestrant + Inavolisib + Metformin + Palbociclib
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Fulvestrant Faslodex ICI 182,780 Hormone - Anti-estrogens 31 Faslodex (fulvestrant) is a competitive inhibitor of estrogen that binds and deforms estrogen receptors, and causes inhibition of growth in cultured estrogen-sensitive breast cancer cells and is FDA approved for use in patients with hormone receptor-positive breast cancer (FDA.gov).
Inavolisib Itovebi GDC-0077|RO7113755|RG6114|GDC0077|GDC 0077 PIK3CA inhibitor 27 Itovebi (inavolisib) inhibits PIK3CA, with selectivity for mutant PIK3CA over wild-type PIK3CA, potentially resulting in increased apoptosis and decreased growth of PIK3CA-mutant tumors (PMID: 36455032). Itovebi (inavolisib) in combination with Ibrance (palbociclib) and Faslodex (fulvestrant) is FDA-approved for use in patients with endocrine-resistant, hormone receptor (HR)-positive, ERBB2 (HER2)-negative, locally advanced or metastatic breast cancer harboring PIK3CA mutations (FDA.gov).
Metformin Glucophage Apo-Metformin mTOR Inhibitor 51 Glucophage (metformin) inhibits part of the mitochondrial respiratory chain and may exert antineoplastic effects through inhibition of mTOR and is FDA approved for type 2 diabetes (FDA.gov).
Palbociclib Ibrance PD0332991|PD-0332991 CDK4/6 Inhibitor 14 Ibrance (palbociclib) is a selective inhibitor of cyclin-dependent kinase 4 (CDK4) and 6 (CDK6) (PMID: 19874578). Ibrance (palbociclib) is approved in combination with an aromatase inhibitor in postmenopausal patients with ER-positive, ERBB2 (HER2)-negative metastatic breast cancer, and in combination with Faslodex (fulvestrant) in patients with ER-positive, ERBB2 (HER2)-negative metastatic breast cancer (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03424005 Phase Ib/II Fulvestrant + Inavolisib + PF-07220060 Fulvestrant + Inavolisib + Metformin Fulvestrant + Inavolisib + Metformin + Palbociclib Empagliflozin + Fulvestrant + Inavolisib Empagliflozin + Fulvestrant + Inavolisib + Palbociclib Inavolisib + Trastuzumab deruxtecan Abemaciclib + Inavolisib + Letrozole Fulvestrant + Inavolisib + Ribociclib Abemaciclib + Fulvestrant + Inavolisib Inavolisib + Letrozole + Ribociclib A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer (Morpheus-panBC) Recruiting USA | ISR | GBR | FRA | ESP | DEU | AUS 2


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