Therapy Detail
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| Therapy Name | Daraxonrasib + RMC-5127 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Daraxonrasib | RMC 6236|RMC6236|RMC-6236 | RAS Inhibitor (Pan) 14 | Daraxonrasib (RMC-6236) forms a binary complex with CypA, which prevents GTP-bound RAS from interacting with downstream effectors, potentially leading to anti-tumor activity (Cancer Res 2022;82(12_Suppl): Abstract nr 3597, PMID: 38593348). | |
| RMC-5127 | RMC5127|RMC 5127 | KRAS Inhibitor 31 | RMC-5127 is a mutant-selective tri-complex inhibitor of RAS G12V, which potentially decreases tumor growth (Cancer Res (2024) 84 (6_Supplement): 3340). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07349537 | Phase I | RMC-5127 Cetuximab + RMC-5127 Daraxonrasib + RMC-5127 | Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors | Recruiting | USA | 0 |
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