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Drug Name RMC-6236
Trade Name
Synonyms RMC 6236|RMC6236
Drug Descriptions

RMC-6236 forms a binary complex with CypA, which prevents GTP-bound RAS from interacting with downstream effectors, potentially leading to anti-tumor activity (Cancer Res 2022;82(12_Suppl): Abstract nr 3597, PMID: 38593348).

DrugClasses RAS Inhibitor (Pan) 11
CAS Registry Number NA
NCIT ID C188048

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + RMC-6236 Bevacizumab Fluorouracil Irinotecan Leucovorin Oxaliplatin RMC-6236 0 1
Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + RMC-6236 Bevacizumab Fluorouracil Leucovorin Oxaliplatin RMC-6236 0 1
Carboplatin + Pembrolizumab + Pemetrexed Disodium + RMC-6236 Carboplatin Pembrolizumab Pemetrexed Disodium RMC-6236 0 1
Cetuximab + Fluorouracil + Leucovorin + Oxaliplatin + RMC-6236 Cetuximab Fluorouracil Leucovorin Oxaliplatin RMC-6236 0 1
Cetuximab + RMC-6236 Cetuximab RMC-6236 0 1
Cisplatin + Pembrolizumab + Pemetrexed Disodium + RMC-6236 Cisplatin Pembrolizumab Pemetrexed Disodium RMC-6236 0 1
Gemcitabine + Nab-paclitaxel + RMC-6236 Gemcitabine Nab-paclitaxel RMC-6236 0 1
HRX-0233 + RMC-6236 HRX-0233 RMC-6236 0 0
Pembrolizumab + RMC-6236 Pembrolizumab RMC-6236 0 1
RMC-6236 RMC-6236 0 1
RMC-6236 + RMC-6291 RMC-6236 RMC-6291 0 1
RMC-6236 + unspecified PD-1 antibody RMC-6236 unspecified PD-1 antibody 0 0


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