Therapy Detail
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| Therapy Name | JNJ-88549968 + Ruxolitinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| JNJ-88549968 | JNJ88549968|JNJ 88549968 | CD3 Antibody 121 | JNJ-88549968 is a bispecific antibody that targets CALR mutations and CD3, which potentially induces an immune response against tumor cells with CALR mutations and inhibits tumor growth (Blood (2023) 142 (Supplement 1): 1777). | |
| Ruxolitinib | Jakafi | INCB 18424|INCB018424|INCB18424 | JAK1 Inhibitor - ATP competitive 5 JAK2 Inhibitor - ATP competitive 15 | Jakafi (ruxolitinib) is an inhibitor of protein tyrosine kinases JAK1 and JAK2, thus resulting in reduced inflammation and reduced proliferation (PMID: 22474318). Jakafi (ruxolitinib) is FDA approved to treat bone marrow cancer, specifically intermediate or high-risk myelofibrosis (FDA.gov) |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06150157 | Phase I | JNJ-88549968 JNJ-88549968 + Ruxolitinib JNJ-88549968 + Momelotinib | A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms | Recruiting | USA | ITA | ISR | GBR | FRA | ESP | DEU | CAN | 0 |
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