Therapy Detail
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| Therapy Name | MK-1084 + Patritumab deruxtecan |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| MK-1084 | MK 1084|MK1084|Calderasib | KRAS G12C inhibitor 36 | MK-1084 is a selective inhibitor of KRAS G12C, which inhibits downstream signaling, potentially resulting in decreased tumor cell proliferation, and antitumor activity (NCI Drug Dictionary, Ann Oncol 34 (2023): S466-S467). | |
| Patritumab deruxtecan | U3-1402|HER3-DXd|U3 1402|U31402 | HER3 (ERBB3) Antibody 28 | Patritumab deruxtecan (U3-1402) is an antibody-drug conjugate (ADC) comprising an ERBB3 (HER3) antibody and Exatecan, which once internalized may result in apoptotic cell death (PMID: 31395690, PMID: 31661465, PMID: 31471314). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07286149 | Phase Ib/II | Cetuximab + MK-1084 MK-1084 + SKB264 MK-1084 + Patritumab deruxtecan | A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F) | Recruiting | USA | ISR | 0 |
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