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Drug Name MK-1084
Trade Name
Synonyms MK 1084|MK1084
Drug Descriptions

MK-1084 is a selective inhibitor of KRAS G12C, which inhibits downstream signaling, potentially resulting in decreased tumor cell proliferation, and antitumor activity (NCI Drug Dictionary, Ann Oncol 34 (2023): S466-S467).

DrugClasses KRAS G12C inhibitor 34
CAS Registry Number NA
NCIT ID C185288

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + MK-1084 + Pembrolizumab + Pemetrexed Disodium Carboplatin MK-1084 Pembrolizumab Pemetrexed Disodium 0 1
Cetuximab + Fluorouracil + Leucovorin + MK-1084 + Oxaliplatin Cetuximab Fluorouracil Leucovorin MK-1084 Oxaliplatin 0 1
Cetuximab + MK-1084 Cetuximab MK-1084 0 1
MK-1084 MK-1084 0 1
MK-1084 + Pembrolizumab MK-1084 Pembrolizumab 0 2


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