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Drug Name | MK-1084 |
Trade Name | |
Synonyms | MK 1084|MK1084 |
Drug Descriptions |
MK-1084 is a selective inhibitor of KRAS G12C, which inhibits downstream signaling, potentially resulting in decreased tumor cell proliferation, and antitumor activity (NCI Drug Dictionary, Ann Oncol 34 (2023): S466-S467). |
DrugClasses | KRAS G12C inhibitor 34 |
CAS Registry Number | NA |
NCIT ID | C185288 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Carboplatin + MK-1084 + Pembrolizumab + Pemetrexed Disodium | Carboplatin MK-1084 Pembrolizumab Pemetrexed Disodium | 0 | 1 |
Cetuximab + Fluorouracil + Leucovorin + MK-1084 + Oxaliplatin | Cetuximab Fluorouracil Leucovorin MK-1084 Oxaliplatin | 0 | 1 |
Cetuximab + MK-1084 | Cetuximab MK-1084 | 0 | 1 |
MK-1084 | MK-1084 | 0 | 1 |
MK-1084 + Pembrolizumab | MK-1084 Pembrolizumab | 0 | 2 |