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Therapy Name ALTA3263 + Fluorouracil + Leucovorin + Oxaliplatin
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ALTA3263 ALTA-3263|ALTA 3263 KRAS G12C inhibitor 36 KRAS G12D Inhibitor 27 ALTA3263 is a an isoform-selective inhibitor of KRAS with activity against KRAS G12C, KRAS G12D, and KRAS G12V, which reduces downstream signaling and potentially decreases tumor cell viability and tumor growth (Eur J Cancer 211 (2024): 114537).
Fluorouracil Adrucil 5-FU|5-Fluorouracil Chemotherapy - Antimetabolite 14 Adrucil (fluorouracil) is an antimetabolite chemotherapeutic agent that interferes with DNA and RNA synthesis, thereby preventing cancer cell growth (PMID: 28520376). Adrucil (fluorouracil) is FDA-approved for use in patients with adenocarcinoma of the colon, rectum, breast, stomach, and pancreas (FDA.gov).
Leucovorin Wellcovorin Calcium folinate|Calcium citrovorum factor|folinic acid Chemotherapy - Antimetabolite 14 Wellcovorin (leucovorin) is a metabolite of folate that enhances the efficacy of fluoruracil (PMID: 32490554).
Oxaliplatin Eloxatin Diaminocyclohexane Oxalatoplatinum Chemotherapy - Platinum 7 Eloxatin (oxaliplatin) is comprised of a platinum complex, which causes DNA-platinum cross-links, inhibition of DNA replication and transcription, and cell toxicity, and is FDA approved for colorectal cancer (FDA.gov).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06835569 Phase I ALTA3263 + Pembrolizumab ALTA3263 + Cetuximab + Fluorouracil + Leucovorin + Oxaliplatin ALTA3263 ALTA3263 + Midazolam ALTA3263 + Cetuximab ALTA3263 + Cetuximab + Gemcitabine + Nab-paclitaxel ALTA3263 + Cisplatin + Pembrolizumab + Pemetrexed Disodium ALTA3263 + Carboplatin + Pembrolizumab + Pemetrexed Disodium ALTA3263 + Gemcitabine + Nab-paclitaxel ALTA3263 + Fluorouracil + Leucovorin + Oxaliplatin A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations Recruiting USA 0


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